UNIT 10 Waycross College CHEM 2401K

Alkyl Halides: Nuclophilic Substitution and Elimination

SPECIFIC LEARNING OBJECTIVES:

The learner will:

1. write rate law expressions for nucleophilic substitution reactions.

2. write step-by-step reactions and recognize the rate determining steps.

3. draw the structure of products predicted by nucleophilic substitution.

4. define the terms S_n¹ and S_n².

5. list the factors that influence whether a reaction for a secondary halide will be S_n¹ or S_n².

6. list the order of reactivity of the different types of alkyl halides towards either S_n¹ or S_n² reactions.

7. have a working knowledge of the preparation of alkyl halides.

8. have a working knowledge of the reactions of alkyl halides.

9. know about movement of hydrogen and methyl groups in formation of more stable carbocations.

10. discuss and distinguish among E₁ and E₂ reaction mechanisms.

11. Compare and contrast SN2, SN1, E2 and E1 (conditions under which each is favored).

LEARNING GUIDE

1. Read chapter 10 in Organic Chemistry: A Biological Approach by McMurry

2. Do the following exercises: 30, 31, 33, 37, 39, 43, 44